Apr 06, 2006  The carcinogenic exposures are mainly inhalatory and the authors therefore studied associations between occupational exposure to eight different organic dusts and respiratory cancers in Finland. (CI) adjusted for age, period, and social class were calculated for each organic dust using the economically active population as the. Darslik jar referat haqida,pactos y senales,p s i really like you how i survived. Renaissance,pagan dream of the renaissance,pacific vortex,ozora powder.

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Methods The authors followed up a cohort of all economically active Finns born between 1906 and 1945 for 30 million person‐years during 1971–95. Incident cases of nasal, laryngeal, and lung cancer and mesotheliomas were identified through a record linkage with the Finnish Cancer Registry. Occupations from the population census in 1970 were converted to exposures to eight organic dusts with a job‐exposure matrix (FINJEM). Cumulative exposure (CE) was calculated as a product of prevalence, level, and estimated duration of exposure. Standardised incidence ratios (SIR) and 95% confidence intervals (CI) adjusted for age, period, and social class were calculated for each organic dust using the economically active population as the reference. Results A total of 20 426 incident cases of respiratory cancer were observed. Slightly increased risk was observed among men exposed to wood dust for nasal cancer (SIR 1.42, 95% CI 0.79 to 2.44).

For laryngeal cancer, men exposed to plant dust (mainly grain millers) had a raised SIR in the high exposure class (SIR 3.55, 95% CI 1.30 to 7.72). Men exposed to wood dust had a raised SIR for lung cancer, but only in the low exposure class (SIR 1.11, 95% CI 1.04 to 1.18).

Women exposed to wood dust showed an increased SIR for mesotheliomas in the low exposure class (SIR 4.57, 95% CI 1.25 to 11.7) and some excess in the medium exposure category. Organic dusts are established causes of respiratory tract irritation and allergy but their significance as occupational carcinogens is mostly unknown. Exposure to organic dusts occurs in many industries and occupations, and the number of people exposed is high.

The International Agency for Research on Cancer (IARC) has published monographs on cancer risks in the textile, leather, and wood industries where exposure to organic dusts is frequent.,, Textile manufacturing industry has been classified as possibly carcinogenic to humans (group 2B) by the IARC. There is limited evidence that the risk of cancer of the nasal cavity among weavers is increased. There is no evidence to suggest an association between work in the leather industry and respiratory cancer according to the IARC monograph. Wood dust has been classified as carcinogenic to humans (group 1) by the IARC, mainly based on evidence on nasal cancer among workers predominantly exposed to hardwood dusts.