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Key:RZVAJINKPMORJF-UHFFFAOYSA-N Y Paracetamol, also known as acetaminophen and APAP, is a medication used to treat. It is typically used for mild to moderate pain relief. There is mixed evidence for its use to relieve fever in children. It is often sold in combination with other medications, such as in many. Paracetamol is also used for severe pain, such as and pain after surgery, in combination with. It is typically used either by mouth or, but is also available.

Effects last between 2 to 4 hours. Paracetamol is generally safe at recommended doses. The recommended maximum daily dose for an adult is 3 or 4 grams. Higher doses may lead to toxicity, including.

Serious skin rashes may rarely occur. It appears to be safe during and when. In those with liver disease, it may still be used, but in lower doses. It is classified as a mild. It does not have significant activity.

How it works is not entirely clear. Paracetamol was first made in 1877. It is the most commonly used medication for pain and fever in both the United States and Europe. It is on the, which lists the most effective and safe medicines needed in a. Paracetamol is available as a with trade names including and, among others. The wholesale price in the is less than 0.01 per dose. In the United States, it costs about US$0.04 per dose.

In 2016, it was the 17th most prescribed medication in the United States, with more than 29 million prescriptions. Contents • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • • Medical uses [ ] Fever [ ] Paracetamol is used for reducing in people of all ages. The recommends that paracetamol be used to treat fever in children only if their temperature is higher than 38.5 °C (101.3 °F). The efficacy of paracetamol by itself in children with fevers has been questioned and a meta-analysis showed that it is less effective than. Paracetamol does not have significant effects.

Pain [ ] Paracetamol is used for the relief of mild to moderate pain. The use of the intravenous form for short-term pain in people in the emergency department is supported by limited evidence.

Osteoarthritis [ ] The recommends paracetamol as one of several treatment options for people with arthritis pain of the hip, hand, or knee that does not improve with exercise and weight loss. A 2015 review, however, found it provided only a small benefit in. Paracetamol has relatively little anti-inflammatory activity, unlike other common analgesics such as the (NSAIDs), and, but ibuprofen and paracetamol have similar effects in the treatment of headache.

Paracetamol can relieve pain in mild arthritis, but has no effect on the underlying inflammation, redness, and swelling of the joint. It has properties comparable to those of, while its anti-inflammatory effects are weaker. It is better tolerated than aspirin due to concerns about bleeding with aspirin. Lower back [ ] Based on a systematic review, paracetamol is recommended by the as a first-line treatment for lower back pain. In contrast, the found good evidence for NSAIDs but only fair evidence for paracetamol, while other systematic reviews have concluded that evidence for its efficacy is lacking entirely. Headaches [ ] A joint statement of the German, Austrian, and Swiss headache societies and the German Society of Neurology recommends the use of paracetamol in combination with caffeine as one of several first-line therapies for treatment of tension or headache.

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In the treatment of acute migraine, it is superior to placebo, with 39% of people experiencing pain relief at 1 hour compared with 20% in the control group. Postoperative [ ] Paracetamol combined with NSAIDs may be more effective for treating postoperative pain than either paracetamol or NSAIDs alone.

Teeth [ ] NSAIDs such as ibuprofen,, and are more effective than paracetamol for controlling dental pain or pain arising from dental procedures; combinations of NSAIDs and paracetamol are more effective than either alone. Paracetamol is particularly useful when are contraindicated due to hypersensitivity or history of gastrointestinal ulceration or bleeding. It can also be used in combination with NSAIDs when these are ineffective in controlling dental pain alone. The of preoperative analgesics for additional pain relief in children and adolescents shows no evidence of benefit in taking paracetamol before dental treatment to help reduce pain after treatment for procedures under local anaesthetic, but the quality of evidence is low. Other [ ] The efficacy of paracetamol when used in combination with weak opioids (such as ) improved for about 50% of people, but with increases in the number experiencing side effects.